Instability and uncertainty, which have recently become integral features of the global economic environment, not only create additional risks for international business due to exchange rate fluctuations, political and economic crises, but can also become a source of new opportunities for stimulating innovative activities, search for fundamentally new sustainable business models, as well as the development of new market outlets. Today, Ukrainian and international companies are forced to demonstrate adaptability and flexibility in supply chain management strategies, market diversification, use of new technologies and digitalization to reduce the impact of economic instability on business processes and transform existing business models in the terms of the process of adapting to growing market uncertainty. In this context, the roundtable will provide a platform for discussion by representatives of the business and scientific community of current theoretical and applied aspects of the impact of global instability on international business. Participants of the roundtable will have the opportunity to discuss the following: challenges faced by enterprises due to unpredictable changes in the economic, political and social conditions of doing business; modern strategies of international business development in conditions of global instability; the influence of global economic trends on the transformation of key strategies of international business.